Identifying potential genetic epistasis implicated in Alzheimer's disease via detection of SNP-SNP interaction on quantitative trait CSF Aβ42

J Li, D Chen, H Liu, Y Xi, H Luo, Y Wei, J Liu… - Neurobiology of …, 2024 - Elsevier
… Although genome-wide association studies have identified … genome-wide SNP-SNP interaction
on cerebrospinal fluid Aβ 42 … a genome-wide epistasis detection study in the ADNI cohort

A GPU-based approach for detecting genome-wide SNP-SNP interactions of quantitative trait in ADNI cohorts

Q Zhang, H Liu, L Ao, H Liang… - 2022 IEEE International …, 2022 - ieeexplore.ieee.org
… The phenotype used in this paper is CSF Qt. Using … the variance explained by interaction
term on T-tau/Aβ42. The … ., “Genome-wide association and interaction studies of CSF

[HTML][HTML] Microglial activation, tau pathology, and neurodegeneration biomarkers predict longitudinal cognitive decline in Alzheimer's disease continuum

YH Chen, RR Lin, HF Huang, YY Xue… - Frontiers in Aging …, 2022 - frontiersin.org
… in cerebrospinal fluid (CSF) and plasma to predict longitudinal cognition status using
Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. … in genome-wide association studies

Association and interaction of TOMM40 and PVRL2 with plasma amyloid-β and Alzheimer's disease among Chinese older adults: a population-based study

X Liang, C Liu, K Liu, L Cong, Y Wang, R Liu, W Fa… - Neurobiology of …, 2022 - Elsevier
… Indeed, the genome-wide association studies (GWAS) have identified a large number of …
from ADNI database showed that TOMM40 was associated with cerebrospinal fluid AD …

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease

J Stevenson-Hoare, A Heslegrave, G Leonenko… - Brain, 2023 - academic.oup.com
… a genome-wide association study for association of disease … Genome-wide association
studies (GWAS) of CSF … for clinical AD diagnosis in our cohort (over and above commonly used …

Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia

LM Reus, IE Jansen, BM Tijms, PJ Visser, N Tesi… - Brain, 2024 - academic.oup.com
Genome-wide association studies have successfully … AD CSF biomarkers (Aβ42, t-tau, p-tau
and t-tau/ Aβ42 ratio) … validation cohorts (ADC cohort: 4 rs4637258, P = 0.01; ADNI cohort

Association of rs2072446 in the NGFR gene with the risk of Alzheimer's disease and amyloid‐β deposition in the brain

CY He, ZT Wang, YY Shen, AY Shi… - CNS Neuroscience …, 2022 - Wiley Online Library
Genome-wide association studies (GWAS) have identified more than 50 genetic risk factors
… study on the genome-wide network-based pathway analysis of CSF t-tau/Aβ42 ratio in the …

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease

DP Veitch, MW Weiner, PS Aisen… - Alzheimer's & …, 2022 - Wiley Online Library
… phenotype in a genome-wide association study (GWAS) and … candidate interactions identified
in a genome-wide epistasis … in participants positive for CSF t-tau/Aβ42. This supports an …

Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer's disease

H Hu, L Tan, YL Bi, W Xu, L Tan, XN Shen… - Translational …, 2021 - nature.com
… Subsequent genome-wide association studies identified a … on these three CSF biomarkers
(Aβ42, p-tau/Aβ42, t-tau/Aβ42) … changes of CSF AD core biomarkers in a large cohort of …

Correlation between Blood Monocytes and CSF Tau in Alzheimer's Disease: The Effect of Gender and Cognitive Decline

CGV Cimiotti, P Paganetti, S Rossi, E Soldini, L Sacco - NeuroSci, 2023 - mdpi.com
Genome-wide association studies (GWAS) have uncovered … Much evidence has been
produced on the interaction … (ADNI) cohort revealed that women with positive CSF biomarkers …